In Greek as well as Roman mythology, Hygieia (also Hygiea or Hygeia in Ancient Greek), was one of the Asclepiadae; the sons and daughters of the god of medicine, Asclepius, and his wife Epione. Hygieia was the goddess/personification of health, cleanliness and hygiene. Hygieia and her four sisters each performed a facet of Apollo's art: Hygieia (health, cleanliness, and sanitation); Panacea (universal remedy); Iaso (recuperation from illness); Aceso (the healing process); and Aglaïa (beauty, splendor, glory, magnificence, and adornment).
Hygieia also playesd an important part in her father's cult. While her father was more directly associated with healing, she was associated with the prevention of sickness and the continuation of good health. Her name is the source of the word "hygiene". Hygieia was imported by the Romans as a goddess Valetudo, the goddess of personal health, but in time she started to be increasingly identified with the ancient Italian goddess of social welfare, Salus.
At Athens, Hygieia was the subject of a local cult since at least the 7th century BC. "Athena Hygieia" was one of the cult titles given to Athena, as Plutarch recounts of the building of the Parthenon (447-432 BC):
A strange accident happened in the course of building, which showed that the goddess was not averse to the work, but was aiding and co-operating to bring it to perfection. One of the artificers, the quickest and the handiest workman among them all, with a slip of his foot fell down from a great height, and lay in a miserable condition, the physicians having no hope of his recovery.
When Pericles was in distress about this, the goddess [Athena] appeared to him at night in a dream, and ordered a course of treatment, which he applied, and in a short time and with great ease cured the man. And upon this occasion it was that he set up a brass statue of Athena Hygieia, in the citadel near the altar, which they say was there before. But it was Phidias who wrought the goddess's image in gold, and he has his name inscribed on the pedestal as the workman of it.
However, the cult of Hygieia as an independent goddess did not begin to spread out until the Delphic oracle recognized her, and after the devastating Plague of Athens (430-427 BC) and in Rome in 293 BC. In the 2nd century AD, Pausanias noted the statues both of Hygieia and of Athena Hygieia near the entrance to the Acropolis of Athens. Hygieia's primary temples were in Epidaurus, Corinth, Cos and Pergamon.